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Here're a few drawings, please comment Sorry the image is not clear! Gaara Neji conan Okiya

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Posts fixed Hi! I dug around the Internet to see if I could get a full list of interviews Gosho has ever given so far, and this is the fruit of my work. (Lol you can see that Gosho usually gives interviews around April, probably for hyping up the movies.) Of these, I have the raws for Conan Drill, Detective Conan & Kindaichi Case Files, and the Monkey Punch & Aoyama Gosho talk from Endless Youth & Co. I'm thinking about translating them, but I want to make sure they're not translated already - so, I'm wondering if these three interviews are translated already or not? Interviews from other people EDIT: Copy & pasting some older posts I've made:

I've decided to allow commenting in thread. In the event that I need more space I'll request a mod split the topic for discussion and reference. However for now, I'm opening the thread for comment and critique. This is especially for the APTX analysis. Welcome one and all to Kyuu's Detective Conan Toxicology thread! I will be posting analysis of the drugs and toxins found in DC that have been used in conjunction with cases (Yes, that includes APTX). There are THREE CATEGORIES of drugs that I'll be doing: 1) Real (Drugs and Toxins that were 100% identified by the series.) 2) Theoretical (APTX basically) 3) Semi-theoretical (Drugs that are possible IRL, but are not identified by Gosho, and can be determined to some degree of accuracy using the information in manga canon) (unnamed poisons and Conan's tranquilizer mostly) Key Terms that you will need to know and understand before reading my analysis: LD50 - Dosage of a toxic agent that will cause death in 50% of treated animals LC50 - Concentration of a toxic agent that will cause death in 50% of the treated animals T1/2 - Biological half-life. How long it takes the concentration in the biological system to be halved. LOAEL - Lowest observable adverse effect level. The amount of a toxin that causes an observable negative effect (your basic symptoms of poisoning without dying, if you have ever seen a drug commercial, you should know most of them) Bioavailability - How much of a drug reaches circulation unchanged in a biological system. IV is always 100% bioavailability, as it is direct to circulatory system. ADME - Absorption, Distribution, Metabolism, Excretion Absorption - How a drug is/can be administered Distribution - how a drug is distributed throughout the body (and what barriers it needs to pass) Metabolism - how the drug is metabolized by the biological system Excretion - how the drug is expelled from the body Those are the main, if I come to a point where I need to explain the more complex terms, I shall append them. I will make every effort to make this easy to read and understand for all. Drugs will be completely analyzed most likely using Toxnet a lot. I'll be using some other resources as well as needed. Everything will be fully referenced. If you use this information for any reason, PLEASE do the same. The drugs currently in planned to be analyzed are: (links will be added as analysis are done) APTX Tetrodotoxin Potassium Cyanide Sea Snake Venom (erabutoxin) Curare (possibly from poison dart case) Batrachotoxin (possibly from the poison dart case) Chlorine Potassium Chloride Phosphoric Acid Carbon Monoxide Aconitine (by Kjeldahl) More may be added as I reread the chapters and watch the episodes that the ones omitted appeared in while I look everything up. If you want clarification please PM or leave comment on my profile. If you wish to critique feel free to do it in topic. Also, this is being done on my own time, so I'm not sure how many I can/will get done. The ones that I am sure of are the top 3, and Carbon Monoxide. Everything else depends on my time and schedule. That all said, I hope you all enjoy this new project of mine and find it illuminating.

its not like you are going to die, why the pic anyway take care gin

"Remember these two words. They will open up a lot of doors in your life. Push and Pull."

"Good friends are like stars. You don't always see them, but you know they're always there."

T-T I'll miss you.... And you're right about all the members. I don't come on anymore because I have no idea who all these new people are, and the old ones don't go on as much.

Considering he has more F.B.I. experience than Jodie or Andre, yes, I believe he knows fully. On the most recent podcast we discuss this actually. I feel like he knows full well who Sera is.

looking forward to see it

Alright, these are my suspicions: First, I don't want to suspect a lot of the characters who are close to Shinichi, so basically anybody who has helped him (I'm not a fan of backstabbing I guess ). So I refuse to suspect Agasa! I even refuse to suspect Ran's mom. So here's my guess: Haibara's mom or dad. If i had to guess between the two I'd guess her dad. My reasoning: -Haibara will be suprised by the boss's identity. I HOPE she would be suprised to find out here mom/dad is not only alive but running the BO. I also suspect this since it was mentioned only "Haibara would be suprised", possibly indicating Conan wasn't suprised (However Conan could have already deduced as much so he wouldn't be suprised). -The boss is somebody introduced to the series already. Although only mentioned, Haibara's parents were in fact 'introduced'. -This kind of twist is something I would expect the author to do to the series, it also seems like a good way to disapoint as minimal fans as possible without introducing a new character. Reasons against my deduction: (lol DC is making me talking like a wanna-be detective ) -Haibara's parents are supposed to be dead. Ok, well this is the most obvious reason against my theory; but I mean c'mon! Somebody using a trick to fake their own death? Not even close to impossible in the world of DC. -Would Haibara's parents target/kill their own daughter (Haibara/her sister)? Well ok let's think about this based on personality. Take Gin for example, a ruthless killer who will attempt to silence anybody he sees a threat to the organization. What if we assume the boss is the same if not worse? Killing they're own daugther might be an afterthought to them. -The boss's favourite is Vermouth. As of now it would seem pretty difficult to connect the two so that is a factor against my theory. -Then there's the unknown information such as how their name relates to the orgainization's name and also how it relates to that seven crow business. I've also been thinking of possible scenarios for havng Haibara's father/mother as the boss. For example let's say it's her father Atsushi and he killed his wife because she wanted to free Haibara and her sister from the organization, and pretended to kill himself off and became the boss of the organization (Maybe he wasn't the first boss!). Also I thought maybe he could die in the end too, and maybe as he's dieing finally says something decent to Haibara as his final words like "sorry". Although only saying sorry might be a bit lame of an ending . Lemme know what you guys think, and also I just made this account so... Nice to meet you guys!

[Complete] Updates: 11 May 2012: added perspective for LD50 11 May 2012: Added oral LD50 and LD100 data for mice and approximate LD50 for humans. Added note on comparison to amounts used in DC. *all information provided here is from Toxnet unless otherwise noted* Structure: Chemical Formula: KCN Appearance: White crystalline powder image from Wikipedia LOAEL (lowest observable adverse effect level): 1.2mg/kg LD50(Inhalation): ~150-300mg/kg (Time to death ranging from 30min to immediate) from HPA LD50 Inhalation Perspective: The average adult in the USA is 86kg (~190lbs). So it would take approximately 25,800mg (or 0.9oz) of KCN to kill an average USA Adult male. To further simplify, that is slightly less than 1.5 tablespoons (estimated, based on the the molecular weight of NaCl, which is slightly lighter, using this converter) LD50(oral human): 0.7-2.9 mg/kg (Of CN-) (from health canada) LD50 Perspective estimate (oral human): It would take about 0.25 teaspoon to kill an adult human male, using 1.5mg/kg as an average of pure Cyanide ion. (so it would actually take about double that because Potassium more than doubles mass of cyanide ion) LD50(oral mice): 5-10mg/kg LD50Perspective (oral): Using the same as before, the calculations come to 0.15 teaspoon to kill. Please see notes at the end for additional information and context. LD100 (oral mice): ~40mg/kg LD100Perspective (oral): Using same methods and figures from before it would take 0.7 teaspoons to kill lab mice 100% of the time. T1/2: 20min - 1hr (conversion from Cyanide to thiocyanate) ADME Absorption: Inhalation of airborn crystals (or of HCN after hydrolysis reaction occurs), ingestion, injection (IV), skin absorption Distribution: KCN is distributed by the cardiovascular system (through the blood) It has a higher affinity for Red Blood Cells than plasma. Excretion: 72% excretion by feces and urine, 25% through exhalation, 3% retained in one month. Urine is the primary method after cyanide is converted into thiocyanate, which usually occurs in the first 24h of exposure. Sweat and saliva via HPA Metabolism (Technical stuff incoming): Note: This works for ALL forms of Cyanide! I know other forms of Cyanide have been used by Gosho, but due to the metabolism and mechanism (next section) being identical, I won't do the others unless I find *significant* differences between the forms of cyanide. Note 2: All forms of cyanide are converted into HCN when ingested. The acid of the stomach creates a hydrolysis reaction that converts it. The cyanide ion (just the CN-) is conjugated with Sulphur, which creates the anion thiocyanate (SCN-). This reaction is catalyzed by the enzyme Rhodanese. Rhodanese is produced in MOST ANIMAL TISSUES, so this reaction need not occur in the liver or in the kidneys. It does need the cofactor sulphane-sulfer (via HPA) for this conversion to occur. After its conversion to thiocyanate, it is in such a form that it can be excreted through the urine. Translation for lay people: KCN becomes K+ and CN-. The cyanide reacts with sulphur in the biological system. This is aided by Rhodanese enzyme, which makes this reaction occur faster. After the reaction is done, it is thiocyanate (SCN-). Thiocyanate can be excreted through the urine, thus being expelled. Mechanism of toxicity (aka: how it kills you): Information on the mechanism from Detective Conan Desperate Revival Case is as follows: According to justwantanaccount, the translation I read was wrong. Gosho did describe it as a electron transfer. From justwantanaccount "The original Japanese for the 'electron signaling' is 電子伝達系, which directly translates to 'electron transfer system'" Verdict: Correct. In reality: Cyanide has an affinity for iron in ferric state (Fe3+). This allows it to react with the iron in cytochrome c oxidase in the mitochondria of cells. This interaction blocks cytochrome c's ability to participate in the electron transfers that are involved in cellular respiration. This blocks the cell's utilization of oxygen. Basically what happens is that the Cyanide takes the place of the cytochrome c oxidase's open site for electrons, which would be transferred to oxygen allowing the oxygen to be converted to water for use within the biological system which is for the creation of ATP. Translation for lay people: There is more to this reaction, but I'm sticking to Cyanide here. Basically, Cyanide interacts with iron, iron interacts with enzyme involved in cellular respiration, this prevents electron transfer between enzyme and oxygen, preventing oxygen from being utilized in cellular respiration. This stops cellular respiration and thus oxygen is not used. This naturally leads to death. Note on toxicity as depicted in Detective Conan: Gosho has overestimated the affects of KCN on a human system. From what I have found, that is the estimated in a general system. However, lethal affects are NOT immediate, unless concentrations are significantly higher. 0.25 teaspoons is what can kill on average. According to the data, it took 35-40mg/kg of CN- to kill mice ~100% of the time (all but one died). Now, the time it took until death was 19 minutes at that dosage. This is further cooroborated with a case I found, that stated a woman, after ingesting 2.5g NaCN, died after 30 minutes. Symptoms occur far before it (tingling sensations, and the like) followed by unconsciousness. Death is NOT immediate. On average for a lethal dose in humans takes approximately One hour to kill. Immediate death (as seen in DC) would take significantly more what could be fit into an ice cube with a small cavity created. The amount Gosho uses is probably around 2-5 times off the minimum lethal amount in humans in Desperate Revival (due to an ice plug being needed, the amount couldn't have been more than about ~10-20 milligrams) FINAL NOTE: I excluded a few things for simplicity, such as the the treatment for Potassium Cyanide. I also did not include symptoms of nonlethal exposure or chronic exposure. If you want that information included, please leave a comment in my profile or in the status update announcing the completion of KCN analysis!

Pencil drawing is accepted, this art competition is open to all kind of media. The artwork doesn't have to be big, and I'll go by UK timing. In my time 1st March is end of February, on evening is when submission closes or I make announcement about the competition.

Ahh~ One week left! >.< Gotta work~~ >.<

Is a pencil drawing accepted? I just found out that I ran out of Chinese ink and they don't sell it anywhere here.

What kind of artwork you like to make?

Actually I can tell. I have my ways. That kind will leave trace so I know it's real or fake. That kind is not acceptable.