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It's not the touching/not touching that is the problem here. Shinichi should have noticed that the wind from the ride was obviously blocked by some obstruction. Also, Vodka should have gotten blood on his face, and possibly should have been hit by the severed head as it flew back. Now that I think about it, it was probably Vodka, not the dead guy, who yelled behind Shinichi right before Shinichi felt the blood. There would be no time for the dead guy to yell and the necklace being put on him would have confused him rather than frightened him. Chek has a pet theory the reason Gin and Vodka didn't run away before the police arrived is because they were too busy cleaning themselves up. They couldn't leave while covered in blood.

I've decided to allow commenting in thread. In the event that I need more space I'll request a mod split the topic for discussion and reference. However for now, I'm opening the thread for comment and critique. This is especially for the APTX analysis. Welcome one and all to Kyuu's Detective Conan Toxicology thread! I will be posting analysis of the drugs and toxins found in DC that have been used in conjunction with cases (Yes, that includes APTX). There are THREE CATEGORIES of drugs that I'll be doing: 1) Real (Drugs and Toxins that were 100% identified by the series.) 2) Theoretical (APTX basically) 3) Semi-theoretical (Drugs that are possible IRL, but are not identified by Gosho, and can be determined to some degree of accuracy using the information in manga canon) (unnamed poisons and Conan's tranquilizer mostly) Key Terms that you will need to know and understand before reading my analysis: LD50 - Dosage of a toxic agent that will cause death in 50% of treated animals LC50 - Concentration of a toxic agent that will cause death in 50% of the treated animals T1/2 - Biological half-life. How long it takes the concentration in the biological system to be halved. LOAEL - Lowest observable adverse effect level. The amount of a toxin that causes an observable negative effect (your basic symptoms of poisoning without dying, if you have ever seen a drug commercial, you should know most of them) Bioavailability - How much of a drug reaches circulation unchanged in a biological system. IV is always 100% bioavailability, as it is direct to circulatory system. ADME - Absorption, Distribution, Metabolism, Excretion Absorption - How a drug is/can be administered Distribution - how a drug is distributed throughout the body (and what barriers it needs to pass) Metabolism - how the drug is metabolized by the biological system Excretion - how the drug is expelled from the body Those are the main, if I come to a point where I need to explain the more complex terms, I shall append them. I will make every effort to make this easy to read and understand for all. Drugs will be completely analyzed most likely using Toxnet a lot. I'll be using some other resources as well as needed. Everything will be fully referenced. If you use this information for any reason, PLEASE do the same. The drugs currently in planned to be analyzed are: (links will be added as analysis are done) APTX Tetrodotoxin Potassium Cyanide Sea Snake Venom (erabutoxin) Curare (possibly from poison dart case) Batrachotoxin (possibly from the poison dart case) Chlorine Potassium Chloride Phosphoric Acid Carbon Monoxide Aconitine (by Kjeldahl) More may be added as I reread the chapters and watch the episodes that the ones omitted appeared in while I look everything up. If you want clarification please PM or leave comment on my profile. If you wish to critique feel free to do it in topic. Also, this is being done on my own time, so I'm not sure how many I can/will get done. The ones that I am sure of are the top 3, and Carbon Monoxide. Everything else depends on my time and schedule. That all said, I hope you all enjoy this new project of mine and find it illuminating.

Alright. Since most people on here seem to be going through a depression of some sort, I want to make a place where these people can talk about their problems. When going through tough times, everyone needs someone to support them... We can be each other's pillars. If you don't want to share anything that's going on, that's pefectly fine. But know this: We are here for you. No matter what. If you think you don't have anyone you can't count on in your life, you are wrong. We'll always be here... So don't think you need to go and commit suicide. Everyone deserves life, even if we don't know the meaning of it yet. I'll tell you, if DCW didn't exist, I would've commited suicide by now... So, anyone want to say anything they need to get off their chest? Share anything you deem necessary. Even if you're not depressed, maybe you can give advice to the people who are facing their problems. That would be appreciated... <3 One reason that's causing my depression is that I'm adopted. And now, I want to find my biological parents... *sigh* But I don't want to hurt my parents now. But they say they have information... Let us all face our fears together. We can do it. <3

I know. (Sorry for late reply) *turn sheepish*

Chinese pole gymnastics is very rare. I think it is reasonable to rule it out. Also, the marks on her thighs from the bar are solely perpendicular, whereas Chinese pole forms occur at multiple angles and would create wider angle marks on her thighs. Also, unstable and moving is fine when you are used to it. The uneven parallel bars move quite a bit during rotations, but as that is a predictable movement, it is learned and accommodated for in training. It is a world apart from a jerky coaster in the dark where you have no visual compensation for balance. As for possible, I trust my gymnast source's evaluation that her plan would be unsteady and slip prone (meaning she runs into Shinichi or collides with the guy while trying to loop him) if she did not use the relatively stable brace that Shinichi demonstrated, which of course creates the why did Shinichi not notice conundrum.

Perhaps you are not familiar with pole acrobatics, aka chinese poles. It is completely and entirely possible to get the position needed using the method I suggested. Yup, chinese pole acrobatics. I think it could work. The same amount of leg would be required to stabilize as Shinichi used to demonstrate it too (up to the knee). Just because Shinichi did not/could not do it in his demonstration does not mean its impossible for someone with the proper training. As for the arterial cut, then yeah... Not enough... 3cm spurt with an initial acceleration of .75m/s in conditions at speed ranging from 48-129kmh, with air resistance and extreme wind.... There is no way the blood made it the likely 1m distance to Shinichi and Ran.

Not what I meant. What I meant was not over the side but to one side entirely, locking her legs into one side of the harness, instead of the middle bar on each side, the bar on the far right (if the cars are facing you). If she locked her left leg to the middle portion and interlocked her right around the outside of the right, she should have been able to be far enough off center to prevent wind from being blocked. With her build and skill as a gymnast, she should have been able to do such a feat. And honestly, it would make sense to me that she would want to do that because she wouldn't want to risk touching Shinichi. Looking over the file again, I see what you mean, I totally forgot about that... Though that bothers me... Shinichi nor Ran should have never felt the blood... The heart doesn't pump that strongly so that it could go against physics (as in the forward motion of the car plus the wind) and gush THAT much. It just doesn't, Gosho should have consulted his brother about the strength of the human heart pumping, because even when the heart is racing from adrenaline due to a roller coaster ride, its not strong enough to make that effect. There might have been a light blood spray from the initial cut, but that would not have made it to Shinichi on a roller coaster. Unless all I learned about kinematics is wrong...

CC: "So Mr. Clay, what do you think of Gosho's writing style?" Clay: "Somebody call his momma!"

While she didn't touch him, most people "feel" when someone is super close to them. I know I do... then again this is Shinichi

[Complete] Updates: 11 May 2012: added perspective for LD50 11 May 2012: Added oral LD50 and LD100 data for mice and approximate LD50 for humans. Added note on comparison to amounts used in DC. *all information provided here is from Toxnet unless otherwise noted* Structure: Chemical Formula: KCN Appearance: White crystalline powder image from Wikipedia LOAEL (lowest observable adverse effect level): 1.2mg/kg LD50(Inhalation): ~150-300mg/kg (Time to death ranging from 30min to immediate) from HPA LD50 Inhalation Perspective: The average adult in the USA is 86kg (~190lbs). So it would take approximately 25,800mg (or 0.9oz) of KCN to kill an average USA Adult male. To further simplify, that is slightly less than 1.5 tablespoons (estimated, based on the the molecular weight of NaCl, which is slightly lighter, using this converter) LD50(oral human): 0.7-2.9 mg/kg (Of CN-) (from health canada) LD50 Perspective estimate (oral human): It would take about 0.25 teaspoon to kill an adult human male, using 1.5mg/kg as an average of pure Cyanide ion. (so it would actually take about double that because Potassium more than doubles mass of cyanide ion) LD50(oral mice): 5-10mg/kg LD50Perspective (oral): Using the same as before, the calculations come to 0.15 teaspoon to kill. Please see notes at the end for additional information and context. LD100 (oral mice): ~40mg/kg LD100Perspective (oral): Using same methods and figures from before it would take 0.7 teaspoons to kill lab mice 100% of the time. T1/2: 20min - 1hr (conversion from Cyanide to thiocyanate) ADME Absorption: Inhalation of airborn crystals (or of HCN after hydrolysis reaction occurs), ingestion, injection (IV), skin absorption Distribution: KCN is distributed by the cardiovascular system (through the blood) It has a higher affinity for Red Blood Cells than plasma. Excretion: 72% excretion by feces and urine, 25% through exhalation, 3% retained in one month. Urine is the primary method after cyanide is converted into thiocyanate, which usually occurs in the first 24h of exposure. Sweat and saliva via HPA Metabolism (Technical stuff incoming): Note: This works for ALL forms of Cyanide! I know other forms of Cyanide have been used by Gosho, but due to the metabolism and mechanism (next section) being identical, I won't do the others unless I find *significant* differences between the forms of cyanide. Note 2: All forms of cyanide are converted into HCN when ingested. The acid of the stomach creates a hydrolysis reaction that converts it. The cyanide ion (just the CN-) is conjugated with Sulphur, which creates the anion thiocyanate (SCN-). This reaction is catalyzed by the enzyme Rhodanese. Rhodanese is produced in MOST ANIMAL TISSUES, so this reaction need not occur in the liver or in the kidneys. It does need the cofactor sulphane-sulfer (via HPA) for this conversion to occur. After its conversion to thiocyanate, it is in such a form that it can be excreted through the urine. Translation for lay people: KCN becomes K+ and CN-. The cyanide reacts with sulphur in the biological system. This is aided by Rhodanese enzyme, which makes this reaction occur faster. After the reaction is done, it is thiocyanate (SCN-). Thiocyanate can be excreted through the urine, thus being expelled. Mechanism of toxicity (aka: how it kills you): Information on the mechanism from Detective Conan Desperate Revival Case is as follows: According to justwantanaccount, the translation I read was wrong. Gosho did describe it as a electron transfer. From justwantanaccount "The original Japanese for the 'electron signaling' is 電子伝達系, which directly translates to 'electron transfer system'" Verdict: Correct. In reality: Cyanide has an affinity for iron in ferric state (Fe3+). This allows it to react with the iron in cytochrome c oxidase in the mitochondria of cells. This interaction blocks cytochrome c's ability to participate in the electron transfers that are involved in cellular respiration. This blocks the cell's utilization of oxygen. Basically what happens is that the Cyanide takes the place of the cytochrome c oxidase's open site for electrons, which would be transferred to oxygen allowing the oxygen to be converted to water for use within the biological system which is for the creation of ATP. Translation for lay people: There is more to this reaction, but I'm sticking to Cyanide here. Basically, Cyanide interacts with iron, iron interacts with enzyme involved in cellular respiration, this prevents electron transfer between enzyme and oxygen, preventing oxygen from being utilized in cellular respiration. This stops cellular respiration and thus oxygen is not used. This naturally leads to death. Note on toxicity as depicted in Detective Conan: Gosho has overestimated the affects of KCN on a human system. From what I have found, that is the estimated in a general system. However, lethal affects are NOT immediate, unless concentrations are significantly higher. 0.25 teaspoons is what can kill on average. According to the data, it took 35-40mg/kg of CN- to kill mice ~100% of the time (all but one died). Now, the time it took until death was 19 minutes at that dosage. This is further cooroborated with a case I found, that stated a woman, after ingesting 2.5g NaCN, died after 30 minutes. Symptoms occur far before it (tingling sensations, and the like) followed by unconsciousness. Death is NOT immediate. On average for a lethal dose in humans takes approximately One hour to kill. Immediate death (as seen in DC) would take significantly more what could be fit into an ice cube with a small cavity created. The amount Gosho uses is probably around 2-5 times off the minimum lethal amount in humans in Desperate Revival (due to an ice plug being needed, the amount couldn't have been more than about ~10-20 milligrams) FINAL NOTE: I excluded a few things for simplicity, such as the the treatment for Potassium Cyanide. I also did not include symptoms of nonlethal exposure or chronic exposure. If you want that information included, please leave a comment in my profile or in the status update announcing the completion of KCN analysis!

Looks like I take requests. XD Lawman09 from deviantART asked if I could draw Burningleafshipping for them, and I did, even though I don't really support it. :3 I think I did a reasonably good job. Oh, and I'm in a good mood right now, so first comment gets to request something for me to draw. :V But no ConAi or ShinShi or something like that.

And now, I can ship KaiShin xPPPP Good job~! +1

This is pretty awesome! +1~

conan's face conan plays soccer

Haha, I just thought that one of the paintings were by you, since you said (I think..?) that you were gonna submit one. xPP I see I see~ xD That's too bad then...

You thought the person in place is me? XD Picasso's style is not my favorite, my drawing will be tedious like details of shophouses. I can draw, but it will take up a week, I don't have time left to submit in.

\o/ Hey, I thought you were going to enter too, Miwako-chan!! Congratz, everyone, again!! ^^

Wow, I was tied for Fourth, not that bad. Congrats Kaze-rei you did really well!

I wanna join de gozaru .

either that, or he'll build up a resistance to the tranquilizer, and not be affected by it