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Greetings DCW! I've noticed in my time here, that there is a severe lack of understanding of when or how to use the search function or any other search. So I'm going to give a run through of the different aspects. FIRST! When to use search? Well, the first thing you should always do when starting a topic is check the thread reference guide that Chekhov MacGuffin created! That is a great resource for finding old threads on a variety of topics in relation to Detective Conan. But let's say that you cannot find something similar to the topic you want to create or you are making a topic not in Detective Conan forums (like Chatroom or elsewhere). It is at this point you should always use search. There might already be a topic for what you are creating, or your questions might have already been answered. Where to find search bar (And other searches): Regular search and advanced search act exactly the same way. Advanced allows you to use tags and other parameters, if you know them. Like Date range, Author, and tags. You can also search based on number of posts and number of views. And be aware that the search bar is always there, no matter what (It is the nice thing about IP Boards). On top of that, it will search the specific forum you are in. (So if you are in "General" under Detective Conan. It will only search that forum, unless you select otherwise). And it even goes further than that, being able to search specific threads. (Which is great if you want to find something you know someone wrote in a long thread.) Type of searches (And how to use them): Now there are THREE ways to search this website. The first is the one everyone always tries (if they choose to use search), and subsequently becomes frustrated with. This is known as keyword searching. What does that mean? Well first it means that you can't use words under 4 letters long. This is due to the fact that many 3 letter words and under are too broad or unspecific enough to make the search effective! What it does is this... It will take the words and search all of the words in the forum posts. Trying to find threads in which the words occur. Example: Say like you were looking for Shinichi vs Heiji. If you search that. It will search for the words Shinichi and Heiji. It will disregard the word "vs" So here is a basic search. (I used advanced to show it) Here is the results. Please note how "vs" was completely disregarded, And here is how it actually searches. Notice how the words are NOT in tandem. It finds, in threads, the words. It does not however search thread titles. So that is how that search works! And how to use it. Because of how it is designed, it will give you the most results, but be the least accurate. ------------------------------------------------------------------------------------------ The second is what is known as phrase search. What this is, is a search of a specific phrase. So it completely disregards the under 4 letter rule. To use it is very simple. You enclose the search terms in quotes! And here are the results. Notice that only one result shows. Because it is the only thread with that specific string of words. And that does it for the site specific searching. -------------------------------------------------------------------------------------------------- Yes, I know I said there were three, but it is really more like three and a half. The last one is GOOGLE! You can use Google to search the contents of ANY site in the same two ways as above. Use it if you don't like the site search or just trust Google more. The way it works is that you type into google site:detectiveconanworld.com/forum/ [search query] (Consequently you can also use this to search the wiki too, just use the right site search.) Both the types described above can be used. But because it is using Google's algorithms, the results are a bit different. So here is just a quick example using the same search terms I've been using. Now there is a benefit to using Google over the site's... Google's search is a bit more flexible, and thus it doesn't have any requirements like "No words under four characters" ------------------------------------------------------------------------------------- So I implore everyone to use all the resources available before creating a new thread, or claiming something wasn't available when it was. And I hope this is useful to everyone.

I don't get it why some fans like her more in her Shiho form than in the Ai form. We have barely seen her as an adult, and the combination of the mentality of a grown-up genius with a child's physical appearance is more intriguing imo. Same with Shinichi and Conan (although in this case there is difference also in personalities, Conan is funnier).

Actually, I have a good answer for your question, you see, the Detective Conan anime screwed up a lot, a lot of cases from Conan arc were moved to Haibara arc, since they're originally in the Conan arc, they couldn't add Haibara to them since that would creat plot-holes, at least that's what I think is the reason.

The middle brother is Shukichi Haneda, and to me it's very obvious, the reason why is because: He doesn't look like Sera/Akai as he looks like their father, he is 28, the perfect age for the middle brother since his classmates from high-school are all 27-29, his skin color matches the skin color that the middle brother has, his name is very similar to Shuichi, in Japan they sometimes name children by similar names, he is very smart, smart enough for Sera to put him as smarter than Shuichi(yes, you might think that he isn't smarter than Akai, but the fact is, in the case he was introduced, he showed that he's even smarter than Conan/Shinichi, although in one case, Yusaku Kudo's cold case, Akai clearly outclassed Conan/Shinichi, but at the same time, Akai says that Conan is better than him at making plans, so that makes them equals to me, and for all we know Sera might've not seen the full extent of Akai's intelligence, and that was in the past anyway, people get smarter by time), he trusted Conan from the first case even though he never met him before(as Conan), the middle brother knows about Shinichi since the Wizard is most likely Shinichi, and the middle brother asked Sera about him, since Shukichi's memory is very good, he would remember child Shinichi's face and know that he is Conan, the middle brother also knew of Conan, that fits with Shukichi because he just met Conan a few cases before he messaged her about him, and finally when he won the Shogi tournament, Shuichi seemed happy as he smiled when he read the news, and the unknown child was also very happy in an unusual way after watching the match. While some people say that he can't be the middle brother because he is famous and Sera should know about his whereabouts, the thing is though, Yumi, of all people didn't know that he was a famous Shogi player, despite dating him, and the detective boys including Haibara didn't realize he was the Taiko Meijin until they looked carefully at the video, besides Sera probably isn't into Shogi so she probably doesn't know the Taiko Meijin(which is also why Yumi couldn't figure out that he's the Taiko Meijin).

Because cooties! :0 I couldn't resist xD Seriously though, you don't have to apologize! Share your opinion without shame

"For every wound there is a scar, and every scar tells a story. A story that says, I SURVIVED"

So you're saying that Gosho is going to toss away ShinRan after shoving it in our faces for nearly 20 years? It's not going to happen, haha. I'll bet on my deathbed that it won't.

11687 I really dislike replying to this thread. The 10-second posting rule makes it hard which is why this sentence exists.

[Carbon Monoxide in Progress] *all information provided here is from [url="http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~QtQRQU:1[/url] unless otherwise noted* *Information is also from Airgas MSDS* Structure: Chemical Formula: CO Appearance: Colorless, tasteless, gas LOAEL: LD50(GI [assumed]): LD50Perspective: LD50(IV mouse): LD50(IP mouse): LD50(SC mouse): LD50(Oral mouse): Perspective on LD50 of TTX Toxicity: T1/2: ADME Absorption: Distribution: Excretion: Metabolism: Mechanism of toxicity (aka: how it kills you): . Notes on accuracy in DC: Final note:

[Complete] Updates: 11 May 2012: added perspective for LD50 11 May 2012: Added oral LD50 and LD100 data for mice and approximate LD50 for humans. Added note on comparison to amounts used in DC. *all information provided here is from Toxnet unless otherwise noted* Structure: Chemical Formula: KCN Appearance: White crystalline powder image from Wikipedia LOAEL (lowest observable adverse effect level): 1.2mg/kg LD50(Inhalation): ~150-300mg/kg (Time to death ranging from 30min to immediate) from HPA LD50 Inhalation Perspective: The average adult in the USA is 86kg (~190lbs). So it would take approximately 25,800mg (or 0.9oz) of KCN to kill an average USA Adult male. To further simplify, that is slightly less than 1.5 tablespoons (estimated, based on the the molecular weight of NaCl, which is slightly lighter, using this converter) LD50(oral human): 0.7-2.9 mg/kg (Of CN-) (from health canada) LD50 Perspective estimate (oral human): It would take about 0.25 teaspoon to kill an adult human male, using 1.5mg/kg as an average of pure Cyanide ion. (so it would actually take about double that because Potassium more than doubles mass of cyanide ion) LD50(oral mice): 5-10mg/kg LD50Perspective (oral): Using the same as before, the calculations come to 0.15 teaspoon to kill. Please see notes at the end for additional information and context. LD100 (oral mice): ~40mg/kg LD100Perspective (oral): Using same methods and figures from before it would take 0.7 teaspoons to kill lab mice 100% of the time. T1/2: 20min - 1hr (conversion from Cyanide to thiocyanate) ADME Absorption: Inhalation of airborn crystals (or of HCN after hydrolysis reaction occurs), ingestion, injection (IV), skin absorption Distribution: KCN is distributed by the cardiovascular system (through the blood) It has a higher affinity for Red Blood Cells than plasma. Excretion: 72% excretion by feces and urine, 25% through exhalation, 3% retained in one month. Urine is the primary method after cyanide is converted into thiocyanate, which usually occurs in the first 24h of exposure. Sweat and saliva via HPA Metabolism (Technical stuff incoming): Note: This works for ALL forms of Cyanide! I know other forms of Cyanide have been used by Gosho, but due to the metabolism and mechanism (next section) being identical, I won't do the others unless I find *significant* differences between the forms of cyanide. Note 2: All forms of cyanide are converted into HCN when ingested. The acid of the stomach creates a hydrolysis reaction that converts it. The cyanide ion (just the CN-) is conjugated with Sulphur, which creates the anion thiocyanate (SCN-). This reaction is catalyzed by the enzyme Rhodanese. Rhodanese is produced in MOST ANIMAL TISSUES, so this reaction need not occur in the liver or in the kidneys. It does need the cofactor sulphane-sulfer (via HPA) for this conversion to occur. After its conversion to thiocyanate, it is in such a form that it can be excreted through the urine. Translation for lay people: KCN becomes K+ and CN-. The cyanide reacts with sulphur in the biological system. This is aided by Rhodanese enzyme, which makes this reaction occur faster. After the reaction is done, it is thiocyanate (SCN-). Thiocyanate can be excreted through the urine, thus being expelled. Mechanism of toxicity (aka: how it kills you): Information on the mechanism from Detective Conan Desperate Revival Case is as follows: According to justwantanaccount, the translation I read was wrong. Gosho did describe it as a electron transfer. From justwantanaccount "The original Japanese for the 'electron signaling' is 電子伝達系, which directly translates to 'electron transfer system'" Verdict: Correct. In reality: Cyanide has an affinity for iron in ferric state (Fe3+). This allows it to react with the iron in cytochrome c oxidase in the mitochondria of cells. This interaction blocks cytochrome c's ability to participate in the electron transfers that are involved in cellular respiration. This blocks the cell's utilization of oxygen. Basically what happens is that the Cyanide takes the place of the cytochrome c oxidase's open site for electrons, which would be transferred to oxygen allowing the oxygen to be converted to water for use within the biological system which is for the creation of ATP. Translation for lay people: There is more to this reaction, but I'm sticking to Cyanide here. Basically, Cyanide interacts with iron, iron interacts with enzyme involved in cellular respiration, this prevents electron transfer between enzyme and oxygen, preventing oxygen from being utilized in cellular respiration. This stops cellular respiration and thus oxygen is not used. This naturally leads to death. Note on toxicity as depicted in Detective Conan: Gosho has overestimated the affects of KCN on a human system. From what I have found, that is the estimated in a general system. However, lethal affects are NOT immediate, unless concentrations are significantly higher. 0.25 teaspoons is what can kill on average. According to the data, it took 35-40mg/kg of CN- to kill mice ~100% of the time (all but one died). Now, the time it took until death was 19 minutes at that dosage. This is further cooroborated with a case I found, that stated a woman, after ingesting 2.5g NaCN, died after 30 minutes. Symptoms occur far before it (tingling sensations, and the like) followed by unconsciousness. Death is NOT immediate. On average for a lethal dose in humans takes approximately One hour to kill. Immediate death (as seen in DC) would take significantly more what could be fit into an ice cube with a small cavity created. The amount Gosho uses is probably around 2-5 times off the minimum lethal amount in humans in Desperate Revival (due to an ice plug being needed, the amount couldn't have been more than about ~10-20 milligrams) FINAL NOTE: I excluded a few things for simplicity, such as the the treatment for Potassium Cyanide. I also did not include symptoms of nonlethal exposure or chronic exposure. If you want that information included, please leave a comment in my profile or in the status update announcing the completion of KCN analysis!

[APTX WiP] Before reading on, a few things. 1) This is incomplete, that means it is as simple as my mind decided to make it (it sort of reads like an intro to a scientific journal in terms of complexity imo) 2) Criticism is welcome, but please refer to my profile comments, the status update where this will be announced or in PM to make it. I'll take all comments and criticisms into account, and work them in as they are applicable. Please don't tell me you don't understand anything, its too early for that. 3) This is very theoretical, so some things will be a stretch of what science is possible, but I WILL try to make it as realistic as possible. 4) No theories about the BO will be given at any point. Aptx analysis… What you will find within is a theoretical analysis of the drug. Since it is theoretical, several possibilities will be discussed, I will make clear what I believe to be most likely. Known facts: APTX = Apotoxin… meaning it is an apoptosis inducing “drug.” It remains in the blood stream and can reactivate itself after antidote has run its course. It is lethal to most. In lab testing there was only one rat to survive by shrinking. It activates/enhances telomerase. One pill of unknown dosage is enough to kill almost instantly. Assumed Drug Data: Appearance: Unknown. In DC it is delivered through a coated pill Structure: Unknown. Anime suggests that it is a complex biomolecule. The data on the computer screen that was erased by Night Baron showed several, albeit random, organic reactions for the “Drug Data.” It is highly likely that the drug’s data would include a synthesis of the proteins it encodes for. LD50 (oral): 50-150mg/kg LD50 Reasoning: This is a drug that is administered through the mouth in a coated pill form. Assuming that it is a collection of virus vectors, it would be low weight but in high dosage to get global effect on the host once administered. T1/2: N/A (It is a virus, it can exist so long as the host’s body allows it and has the means to survive) ADME: Absorption: GI Tract (oral administration) (as far as we have seen this is the only method) Distribution: Likely the cardiovascular initially, but it is possible that the virus is similar to HIV and exists with the lymphatic system and circulatory system once it affects the host. Metabolism: No known metabolism method known. Likely there is none outside of completed antidote. Excretion: After the virus is eaten it is likely expelled as any other, through urine sweat and mucosal ducts. After the host is dead it likely has a self terminating chain, which kills it and allows it to be expelled through the urine, making it impossible to detect within the system. Conclusions to be drawn from the above: Apoptosis is the main pathway in which it kills. Implications of this are that it causes global cellular death. Consequences of this are numerous, including the degradation of skin tissues and other tissues overtime if the biological system is sustained long enough to survive. However, if the drug targets certain tissues first this may be a nonissue. It cannot be a standard drug. Standard drugs have a specific half-life within a biological system. Once the drug has either run its course or been used by an antidote (incomplete or not) it is done, and should not reactivate. Thus, the drug is actually most likely a recombinant strand of DNA that codes for a lethal protein(s) that is delivered by virus vectors and is constantly replicated within the host’s system. Thus, the antidote does not expel and the virus becomes resistant to the antidote, meaning more is needed each time it is administered. This is confirmed by Haibara’s explanation of the dangers of taking the incomplete antidote. (Thus it is actually akin to being afflicted with a virus that will eventually die, and will likely render it undetectable by normal drug analysis) Why does the antidote work while in the system? There are a few possibilities. The first possibility is that it binds to the sites of the activated proteins that the recombinant DNA the virus vector is introducing, and thus disables the activity. The other main possibility is that it binds to the activation site of one of the cofactors or more likely mechanism of reproduction of the proteins that the recombinant DNA encodes for. The latter possibility is highly more likely, acting as an inhibitor would account for several parts of this “incomplete antidote.” By acting as an inhibitor for certain proteins, it may allow in the cease of the reproduction of these proteins. The inhibition can be a factor of heightened antibody presence, which when the components of the alcohol bind, may lead to a secondary binding site being created to bind to the foreign virus, which the APTX is delivered on. This would also explain the cause for alarm for the possibility of resistance, as the virus is likely to mutate to prevent this antidote from working. If the real antidote has the same properties, the incomplete, then it poses a serious risk. To Be Done: -Explanation of the two pathways (apoptosis and telomerase) -Proposed mechanism -Possible metabolism (antidote/regular)