I'd imagine she'd probably go the same way as Akai: colder, more introverted, being unable to forget and move on, still dwelling on the past. Unlike Akai, there would probably be a lot of crying at first. Her tenacious personality means she'd probably take a few years to get over it. She'd probably avoid trying to see Shinichi in person, but she would still read his articles in the newspaper. Kogoro would probably hate Shinichi's guts for depressing Ran. Kogoro and Ran's relationship might degrade a bit. Sonoko would be there as support though and would lift Ran's spirits.