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As much as I love Shiho, considering what Shinichi may think, I think he'd have a really really hard time if Ran leaves him. Shiho mainly helps him in destroying BO and turning himself back, if Shiho's gone, he still got many allies, just that it'd be hard for him to return to Shinichi (but if BO's brought to light, APTX can be studied by other scientists too). Ran just plays a too much important role in Shinichi's life.

There's a live performance of Opening 41 (Found on Detective Conan - The Red Thread's FB fanpage)

1. I'm positive it's an email address, or that's at least what it's referred to most of the time. You can check out this topic: http://www.detectiveconanworld.com/forum/topic/5521-is-the-bosss-number-a-phone-number-or-an-email-address/ 2. The number is #969#6261 (not 0858, Tottori), though it sounds similar to a Kurayoshi area code (Gosho also used this number in particular to prevent prank calls if I'm not mistaken, I think he also chose the number upon calling home) - Gosho said that there is no connection between the two, although we don't really know if he is completely serious or not. There is some more information in the translating interview topic regarding this. 3. The number is mentioned afterwards, but I'm not sure exactly when the last time Conan referenced it was? I think it's brought up again in the Clash of Red and Black series. As mentioned before, there are quite a few people that know the number.