Silver Bullet (drug)

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Haibara remebering Elena's tapes. The tape for her 18th birthday revealed the existence of "Silver Bullet". Tape's contents were revealed between two flashbacks.

"Silver Bullet" is the name given to a mysterious drug created by Elena Miyano and Atsushi Miyano for the Black Organization.


In a tape left for Shiho[1], Elena reveals she had been working on "a truly terrifying drug" the Miyano parents called the Silver Bullet.[2] It was something incredible enough that Elena said they were "putting their hopes on it",[3] and Elena's lab mates had taken to calling it "a dream drug". It was important enough that Elena and Atsushi had to leave behind Shiho and Akemi in order to complete the drug.[3]

After thinking about this message left by Elena, Ai Haibara expresses her resentment that she had only later realized that the drug was something that should have never been made.[3]

The research related to Silver Bullet may have partially or wholly destroyed by a fire which destroyed much of the Miyanos' research and apparently took their lives.[4] If some of it survived, it's possible that Shiho Miyano may have incorporated it into one of her modern projects. At the current time, it is still unstated how Silver Bullet, APTX 4869, and any other research projects the Black Organization are related to one another.


Shiho, won't you regret what you are about to do? If so, I'm totally on your side! Well, it will be you nineteenth birthday next time. Bye-bye, honey. Oh yes, maybe it's about time I told you... The truth is, your mom is making a truly terrifying drug at the moment. My lab mates are getting really excited about it, they say it's like a dream drug. Your dad and I are putting all our hopes on it and calling it the Silver Bullet! But in order to complete the drug, your dad and I will have to leave you and your sister. Please understand, Shiho.

— Part of Elena's message on Shiho's 18th tape.[5]


"Silver Bullet" and "APTX 4869" are two names for the same project

See also: APTX 4869

It is unclear whether Silver Bullet is the Miyano parents' personal nickname for what is currently called APTX 4869, or if it was a closely related project they developed in parallel. Whatever the case, the Miyanos' Silver Bullet drug and Shiho's APTX 4869 are probably closely linked if not the same in-development drug.

Haibara took over her parents' research after they died by reconstructing their work from surviving fragments after a lab fire which supposedly killed her parents.[6] One of these projects was the APTX 4869 project. The proof some version of APTX 4869 existed in the Miyano parents' time lies in a death list which includes the name of a man killed with the drug 17 years prior to the current timeline. Because Shiho had to reconstruct her parents' research from the fragments that survived, intentionally or unintentionally, it's possible that some of what the Miyanos called the Silver Bullet became incorporated into Shiho's modern version of APTX 4869.

Regardless of what the parents' version of APTX 4869 was intended for, those characters who know about the shrinking side effect of Shiho's modern version of APTX 4869 have a tendency to compare it to the Miyanos' research. After watching Haibara shrink, Pisco, who knew about the project the Miyanos worked on, commented that Shiho's parents would be proud of the progress Shiho had made on the drug.[7] During her recollection of the tapes, Haibara was holding and considering the antidote to APTX 4869. She then regrets that she didn't understand the drug was something that should have never been made, strongly implying she had worked on the same drug as well.[3] Lastly, Vermouth, who opposed the Miyanos' research seems to have transposed her distaste onto Shiho's research and Shiho herself.[8]

It is also notable that Vermouth has been a part of the Black Organization long enough to have heard the Miyanos use the name "Silver Bullet",[9] and may have given Conan the same nickname in reference to his deaged state caused by the drug.

During the conversation, where Conan and Haibara discuss APTX 4869 and it's connection to Kohji Haneda's death, Haibara thought 'what they (the organization) wanted me to make, was another drug'. Its possible that the 'other drug' was the intended result of the APTX 4869 research, and maybe that drug had the name 'Silver Bullet'.

See also


  1. ^ Bathroom Murder Case (Manga: 423-425; Anime: 340-341)
  2. ^ Mystery Train (Manga: 821, 823-824; Anime: 702, 704)
  3. ^ a b c d Manga Chapter 821, pg 7: "Mystery Train 「Junction」"
  4. ^ Haibara: And the fact that [Kohji Haneda's] name was on the list of victims who were given APTX 4869, I'd say there's a good chance that Asaka was one of the members of the Black Organization!
    Conan: I don't get it. Kohji Haneda was killed 17 years ago. Then why is his name under mine in the list?
    Haibara: Perhaps the person who compiled the list wasn't going by chronological order. Maybe it was sorted by blood type or something.
    Conan: Wait a minute, so the drug that I was forced to take existed 17 years ago? And you are its creator? How old are you really?
    Haibara: How rude. I've told you before. I am 18 now. Perhaps it was an early prototype of a drug made by my parents. The information for the drug that I created was mostly taken from the burnt remains of the data that my parents left behind.
    Conan: Burnt remains? What do you mean?
    Haibara: Well, the research lab that my parents worked in caught fire, and along with them, most of their research materials were burnt. I heard from the other members of the Organization that it was an accident.
    Well, what I was really ordered to make was another drug, however...
    Manga Volume 89, File 11 (948), Pages 3-4: "The Clenched Scissors"
  5. ^ Manga Volume 78, File 4 (821), pgs 7-8: "Mystery Train: Junction"
  6. ^ Manga Volume 89, File 11 (948), Pages 3-4: "The Clenched Scissors"
  7. ^ Manga Volume 24, File 11, page 9: "The White World"
  8. ^ "If you [Shiho] want to blame someone, blame your parents who took over this foolish research." Episode 345
  9. ^ Vermouth has been in the Organization at least 20 years dated by when she assassinated Jodie's father which is more time than the theoretical maximum 18 years the tapes could be recorded -- dated to Shiho's conception.
APTX 4869
Developers Atsushi MiyanoElena MiyanoShiho Miyano
Victims Shinichi KudoKohji HanedaAmanda HughesMary SeraShiho Miyano
Antidotes Prototype antidoteBaijiu
Related Articles Silver BulletVictim listCase from 17 years agoBlack Organization