APTX 4869 - Revision history

AvidConanContributor: fr

2026-01-24T21:40:52Z

← Older revision		Revision as of 21:40, 24 January 2026
Line 65:		Line 65:
	[[ca:APTX 4869]]		[[ca:APTX 4869]]
	[[de:Apoptoxin 4869]]		[[de:Apoptoxin 4869]]
			[[fr:APTX 4869]]

Nakamura: /* References */

2025-08-30T18:29:22Z

References

← Older revision		Revision as of 18:29, 30 August 2025
Line 55:		Line 55:

	== References ==		== References ==
	~~<references/>~~		{{reflist}}

	{{APTX 4869}}		{{APTX 4869}}
Line 63:		Line 63:
	[[Category:Black Organization]]		[[Category:Black Organization]]

			[[ca:APTX 4869]]
	[[de:Apoptoxin 4869]]		[[de:Apoptoxin 4869]]

Time Lord Enthusiast: Removing episode redirects

2025-08-25T05:18:19Z

Removing episode redirects

← Older revision		Revision as of 05:18, 25 August 2025
Line 6:		Line 6:
	APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of [[Wikipedia: Apoptosis\|apoptosis]]: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contains a component which activates [[Wikipedia: Telomerase\|telomerase]]: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide.<ref>Manga Volume 24, File 10</ref>		APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of [[Wikipedia: Apoptosis\|apoptosis]]: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contains a component which activates [[Wikipedia: Telomerase\|telomerase]]: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide.<ref>Manga Volume 24, File 10</ref>

	In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect is de-aging the target instead of killing them. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[Episode 129]]</ref> so the adult mind and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->		In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect is de-aging the target instead of killing them. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[The Girl from the Black Organization and the University Professor Murder Case\|Episode 129: The Girl from the Black Organization and the University Professor Murder Case]]</ref> so the adult mind and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->

	[[Shinichi Kudo]], [[Shiho Miyano]] and [[Mary Sera]] are the three known people who were de-aged. Shinichi, the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[~~Episode 1~~]]. Later, Shiho was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.		[[Shinichi Kudo]], [[Shiho Miyano]] and [[Mary Sera]] are the three known people who were de-aged. Shinichi, the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[Roller Coaster Murder Case]]. Later, Shiho was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.

	== History ==		== History ==
	[[Atsushi Miyano]] and [[Elena Miyano]] joined the Black Organization as researchers around some months before [[Shiho Miyano]] was born<ref name=f1011>[[Volume 95#File 1011 - Memories of That Woman\|Volume 95, File 1011: "Memories of That Woman"]]</ref> and started developing APTX 4869. [[Vermouth]] may have hinted that there was an earlier project that the Miyanos assumed control over when they joined,<ref>“If you [Shiho] want to blame someone, blame your parents '''who took over''' this foolish research.” Episode 345</ref> perhaps the one Shiho implied was at least 50 years old.<ref>Manga [[Volume 19]], File 9 (189): "The Endangered Ball "; ~~Episodes~~ [[Episode 130~~\|130]]~~-~~[[Episode 131\|~~131]] "Kudo-kun? You would probably never even dream that you are already part of a project the Black Organization has been working on already for half a century."</ref> Regardless, the pair worked on APTX 4869 until they met their untimely deaths in a laboratory fire<ref>Manga [[Volume 89]], File 11 (948), Pages 3-4: "The Clenched Scissors"</ref> which destroyed much of their research, leaving their daughter [[Shiho Miyano]] behind and the project in an unfinished state. The Miyano parents' version of the APTX 4869 was used to kill at least one person, [[Kohji Haneda]] who was murdered 17 years ago and included on Shiho's list of APTX victims.		[[Atsushi Miyano]] and [[Elena Miyano]] joined the Black Organization as researchers around some months before [[Shiho Miyano]] was born<ref name=f1011>[[Volume 95#File 1011 - Memories of That Woman\|Volume 95, File 1011: "Memories of That Woman"]]</ref> and started developing APTX 4869. [[Vermouth]] may have hinted that there was an earlier project that the Miyanos assumed control over when they joined,<ref>“If you [Shiho] want to blame someone, blame your parents '''who took over''' this foolish research.” Episode 345</ref> perhaps the one Shiho implied was at least 50 years old.<ref>Manga [[Volume 19]], File 9 (189): "The Endangered Ball "; [[The Indiscriminate Stadium Threatening Case\|Episode 130-131: The Indiscriminate Stadium Threatening Case]] "Kudo-kun? You would probably never even dream that you are already part of a project the Black Organization has been working on already for half a century."</ref> Regardless, the pair worked on APTX 4869 until they met their untimely deaths in a laboratory fire<ref>Manga [[Volume 89]], File 11 (948), Pages 3-4: "The Clenched Scissors"</ref> which destroyed much of their research, leaving their daughter [[Shiho Miyano]] behind and the project in an unfinished state. The Miyano parents' version of the APTX 4869 was used to kill at least one person, [[Kohji Haneda]] who was murdered 17 years ago and included on Shiho's list of APTX victims.

	Shiho was then groomed to take over their APTX 4869 research project.<ref name="387p7">Manga [[Volume 38]], File 2 (384), pg 7: "An unexpected Treasure"</ref><ref>Manga [[Volume 89]], File 11 (948), Pages 3-4: "The Clenched Scissors</ref> She was educated overseas in America<ref name="387p7"/> before returning to Japan at or before she was 13<ref>13 is the latest age she was codenamed by according to Akai Shuuichi's version of events.</ref>. Shiho advanced the drug to the point where she observed at least one of her lab mice reverting in age.<ref>Shiho's intro when she first explains APTX to Shinichi</ref> She was also ordered to test the most recent, yet still incomplete, version of APTX 4869 on [[Ki'ichiro Numabuchi]], a failed assassin. Shiho received the data about him, but he managed to escape the Black Organization before she could test it on him. The drug was still considered incomplete by the time it was used on [[Shinichi Kudo]]<ref>APTX's nickname is incomplete detective</ref>, but [[Pisco]] implied that Shiho had advanced it significantly since her parents' tenure<ref>[[Volume 24]]</ref>. Shiho boycotted her work, when she couldn't get any answer to why her sister had died. To die by her own hand, she used the poison and ended up getting shrunk, which made her able to escape. It is unknown if the Black Organization has found replacement researchers to continue work on the APTX 4869 project after Shiho's defection.		Shiho was then groomed to take over their APTX 4869 research project.<ref name="387p7">Manga [[Volume 38]], File 2 (384), pg 7: "An unexpected Treasure"</ref><ref>Manga [[Volume 89]], File 11 (948), Pages 3-4: "The Clenched Scissors</ref> She was educated overseas in America<ref name="387p7"/> before returning to Japan at or before she was 13<ref>13 is the latest age she was codenamed by according to Akai Shuuichi's version of events.</ref>. Shiho advanced the drug to the point where she observed at least one of her lab mice reverting in age.<ref>Shiho's intro when she first explains APTX to Shinichi</ref> She was also ordered to test the most recent, yet still incomplete, version of APTX 4869 on [[Ki'ichiro Numabuchi]], a failed assassin. Shiho received the data about him, but he managed to escape the Black Organization before she could test it on him. The drug was still considered incomplete by the time it was used on [[Shinichi Kudo]]<ref>APTX's nickname is incomplete detective</ref>, but [[Pisco]] implied that Shiho had advanced it significantly since her parents' tenure<ref>[[Volume 24]]</ref>. Shiho boycotted her work, when she couldn't get any answer to why her sister had died. To die by her own hand, she used the poison and ended up getting shrunk, which made her able to escape. It is unknown if the Black Organization has found replacement researchers to continue work on the APTX 4869 project after Shiho's defection.
Line 32:		Line 32:

	==== Immortality/anti-aging ====		==== Immortality/anti-aging ====
	One possibility is that the goal of the APTX 4869 is to develop a therapy which will cause immortality, stall or reverse the effects of aging, or extend a human's lifespan. The de-aging effect that occurred when Shinichi and Haibara took APTX 4869 probably indicates the main intent of the drug's development. After [[Pisco]] saw Haibara shrink back to her child form, he commented that he was impressed she had developed the drug to that point, implying that deaging is in the right direction.<ref name="242p9">Manga [[Volume 24]], File 11, page 9: "The White World"</ref> Supporting this is Haibara’s line, "Kudo-kun? You would probably never even dream that you are already part of a project the Black Organization has been working on already for half a century."<ref>Manga [[Volume 19]], File 9 (189): "The Endangered Ball "; ~~Episodes~~ [[Episode 130~~\|130]]~~-~~[[Episode 131\|~~131]]</ref> APTX 4869 is the only known intersection between Shinichi and the Black Organization; meaning that Shinichi's de-aging made him relevant to the Black Organization's project.		One possibility is that the goal of the APTX 4869 is to develop a therapy which will cause immortality, stall or reverse the effects of aging, or extend a human's lifespan. The de-aging effect that occurred when Shinichi and Haibara took APTX 4869 probably indicates the main intent of the drug's development. After [[Pisco]] saw Haibara shrink back to her child form, he commented that he was impressed she had developed the drug to that point, implying that deaging is in the right direction.<ref name="242p9">Manga [[Volume 24]], File 11, page 9: "The White World"</ref> Supporting this is Haibara’s line, "Kudo-kun? You would probably never even dream that you are already part of a project the Black Organization has been working on already for half a century."<ref>Manga [[Volume 19]], File 9 (189): "The Endangered Ball "; [[The Indiscriminate Stadium Threatening Case\|Episode 130-131: The Indiscriminate Stadium Threatening Case]]</ref> APTX 4869 is the only known intersection between Shinichi and the Black Organization; meaning that Shinichi's de-aging made him relevant to the Black Organization's project.

	According to Haibara’s description about APTX 4869<ref name="241p6">Manga [[Volume 24]], File 10 (241), page 6</ref>, APTX 4869 activates telomerase, an enzyme which can increase the number of times a cell can divide, and therefore affect a cell's lifespan and “reproductive potential”. The goal of this might be to revert all non-neural cells to a "youthful", high reproductive potential state. [[Vermouth]]'s unnatural youth is another indicator that the Black Organization may be involved in research towards extending lifespan, halting aging, or rejuvenating the body.		According to Haibara’s description about APTX 4869<ref name="241p6">Manga [[Volume 24]], File 10 (241), page 6</ref>, APTX 4869 activates telomerase, an enzyme which can increase the number of times a cell can divide, and therefore affect a cell's lifespan and “reproductive potential”. The goal of this might be to revert all non-neural cells to a "youthful", high reproductive potential state. [[Vermouth]]'s unnatural youth is another indicator that the Black Organization may be involved in research towards extending lifespan, halting aging, or rejuvenating the body.

Nakamura at 23:03, 20 February 2025

2025-02-20T23:03:54Z

← Older revision		Revision as of 23:03, 20 February 2025
Line 23:		Line 23:
	:''Main article: [[Prototype antidote]]''		:''Main article: [[Prototype antidote]]''
	[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]		[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]
	Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The first antidote was [[~~baiganr~~]], which only works once as the body develops resistance to it. The key component in ~~baiganr~~ was incorporated in a prototype antidote developed by Haibara.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>		Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The first antidote was ''[[paikaru]]'', which only works once as the body develops resistance to it. The key component in paikaru was incorporated in a prototype antidote developed by Haibara.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>

	Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things ~~baiganr~~) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.		Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things paikaru) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.

	== Speculation ==		== Speculation ==

SocietyBox: /* Antidote */ baijiu → baiganr

2025-02-04T19:26:52Z

Antidote: baijiu → baiganr

← Older revision		Revision as of 19:26, 4 February 2025
Line 23:		Line 23:
	:''Main article: [[Prototype antidote]]''		:''Main article: [[Prototype antidote]]''
	[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]		[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]
	Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The first antidote was [[~~baijiu~~]], which only works once as the body develops resistance to it. The key component in ~~baijiu~~ was incorporated in a prototype antidote developed by Haibara.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>		Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The first antidote was [[baiganr]], which only works once as the body develops resistance to it. The key component in baiganr was incorporated in a prototype antidote developed by Haibara.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>

	Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things ~~[[baijiu]]~~) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.		Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things baiganr) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.

	== Speculation ==		== Speculation ==

AvidConanContributor: /* Name origin */

2025-02-04T17:59:27Z

Name origin

← Older revision		Revision as of 17:59, 4 February 2025
Line 18:		Line 18:

	== Name origin ==		== Name origin ==
	APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Ro-ku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[Wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. This incompleteness could mean that APTX 4869 was originally developed to keep young, not to kill people.		APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Ro-Ku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[Wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. This incompleteness could mean that APTX 4869 was originally developed to keep young, not to kill people.

	== Antidote ==		== Antidote ==

AvidConanContributor: /* Name origin */ 6 can be pronounced as "ro" instead of "roku"; minor wording edit

2025-02-04T17:59:02Z

Name origin: 6 can be pronounced as "ro" instead of "roku"; minor wording edit

← Older revision		Revision as of 17:59, 4 February 2025
Line 18:		Line 18:

	== Name origin ==		== Name origin ==
	APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-~~Roku~~"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[Wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. ~~Maybe this means~~ that APTX 4869 was developed to keep young, not kill people.		APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Ro-ku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[Wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. This incompleteness could mean that APTX 4869 was originally developed to keep young, not to kill people.

	== Antidote ==		== Antidote ==

SocietyBox: expand

2025-02-04T06:59:37Z

expand

← Older revision		Revision as of 06:59, 4 February 2025
Line 1:		Line 1:
	[[File:APTX 4869.jpg\|thumb\|right\|200px\|APTX 4869]]		[[File:APTX 4869.jpg\|thumb\|right\|200px\|APTX 4869]]
	'''{{nihongo\|APTX 4869\|アポトキシンよんはちろくきゅう\|Apotokishin Yon-Hachi-Roku-Kyū}}''' is a toxin in the manga and anime franchise ''[[Detective Conan]]''. Nicknamed "~~Prototype~~ Detective" by members of the [[Black Organization]], it is the derivative of an experimental formula of unknown purpose developed by [[Shiho Miyano]] and is used by the Black Organization as an untraceable, lethal poison. Right now, there is a [[prototype antidote]] for it made by Shiho.		'''{{nihongo\|APTX 4869\|アポトキシンよんはちろくきゅう\|Apotokishin Yon-Hachi-Roku-Kyū}}''' is a toxin in the manga and anime franchise ''[[Detective Conan]]''. Nicknamed the "Incomplete Detective" by members of the [[Black Organization]], it is the derivative of an experimental formula of unknown purpose developed by [[Shiho Miyano]] and is used by the Black Organization as an untraceable, lethal poison. Rarely, the toxin de-ages the target instead of killing them. Right now, there is a [[prototype antidote]] for the de-aging made by Shiho.

	== Description ==		== Description ==
Line 8:		Line 8:
	In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect is de-aging the target instead of killing them. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[Episode 129]]</ref> so the adult mind and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->		In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect is de-aging the target instead of killing them. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[Episode 129]]</ref> so the adult mind and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->

	[[Shinichi Kudo~~\|Shinichi~~]], the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[Episode 1]]. Later, [[Shiho ~~Miyano]]~~ was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.		[[Shinichi Kudo]], [[Shiho Miyano]] and [[Mary Sera]] are the three known people who were de-aged. Shinichi, the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[Episode 1]]. Later, Shiho was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.

	== History ==		== History ==
Line 18:		Line 18:

	== Name origin ==		== Name origin ==
	APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Roku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[~~wikipedia~~:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. Maybe this means that APTX 4869 was developed to keep young, not kill people.		APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Roku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[Wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. Maybe this means that APTX 4869 was developed to keep young, not kill people.

	== Antidote ==		== Antidote ==
	:''Main article: [[Prototype antidote]]''		:''Main article: [[Prototype antidote]]''
	[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]		[[File:APTX 4869 given to Shinichi.jpg\|thumb\|200px\|Gin poisons Shinichi.]]
	Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The ~~main ingredient for this reversal is a component found in~~ [[baijiu]], which ~~Haibara has already~~ incorporated in a prototype antidote ~~for the APTX~~.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>		Throughout the series there are several instances in which the APTX was temporarily neutralized and Shinichi and Shiho were returned to their actual age forms. The first antidote was [[baijiu]], which only works once as the body develops resistance to it. The key component in baijiu was incorporated in a prototype antidote developed by Haibara.<ref name="TGDOTW">Manga [[Volume 10]], Files 4-5 (092-095): "The Great Detective of the West"</ref>

	Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things [[baijiu]]) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.		Conan and Haibara briefly reverted to their true age while having rum cake (thought to contain among other things [[baijiu]]) in the live action drama ''[[Shinichi Kudo Returns! Confrontation with the Black Organization]]''.

SocietyBox: fixes

2025-02-04T06:47:23Z

fixes

← Older revision		Revision as of 06:47, 4 February 2025
Line 1:		Line 1:
	[[File:APTX 4869.jpg\|thumb\|right\|200px\|APTX 4869]]		[[File:APTX 4869.jpg\|thumb\|right\|200px\|APTX 4869]]
	'''~~APTX~~ {{nihongo\|4869\|~~四八六九~~\|Yon-Hachi-Roku-Kyū}}'''~~, nicknamed~~ "Prototype Detective" by members of the [[Black Organization]], is ~~a fictional toxin and~~ derivative of an experimental formula of unknown purpose developed by [[Shiho Miyano]]~~, which~~ is used by the Black Organization as an untraceable, lethal poison. Right now, there is a [[prototype antidote]] for it made by Shiho.		'''{{nihongo\|APTX 4869\|アポトキシンよんはちろくきゅう\|Apotokishin Yon-Hachi-Roku-Kyū}}''' is a toxin in the manga and anime franchise ''[[Detective Conan]]''. Nicknamed "Prototype Detective" by members of the [[Black Organization]], it is the derivative of an experimental formula of unknown purpose developed by [[Shiho Miyano]] and is used by the Black Organization as an untraceable, lethal poison. Right now, there is a [[prototype antidote]] for it made by Shiho.

	== Description ==		== Description ==
Line 6:		Line 6:
	APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of [[Wikipedia: Apoptosis\|apoptosis]]: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contains a component which activates [[Wikipedia: Telomerase\|telomerase]]: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide.<ref>Manga Volume 24, File 10</ref>		APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of [[Wikipedia: Apoptosis\|apoptosis]]: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contains a component which activates [[Wikipedia: Telomerase\|telomerase]]: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide.<ref>Manga Volume 24, File 10</ref>

	In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect ~~can in fact~~ de-~~age victims~~. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[Episode 129]]</ref> ~~but~~ the adult ~~personality~~ and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->		In practice, most of the time APTX 4869 works as a lethal poison. [[Gin]] says it can't be detected when used, possibly indicating it leaves few traces that forensic examination could uncover. However, as said by [[Ai Haibara]], a rare side effect is de-aging the target instead of killing them. When talking about her own and Conan's shrinking, she said that the side effect causes everything apart from the nervous system to revert back to a childlike state,<ref>“[Shrinking] is an unexpected side effect. The nervous system is unaffected, but everything else—bones, muscle tissue, internal organs, hair – reverts to a childlike state” (VIZ english version of the quote in volume 18 file 8.)</ref><ref>[[Episode 129]]</ref> so the adult mind and memories remain intact.<!--However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis stabilizes at some point, causing the victim's apparent age to be decreased while leaving higher thought processes, memory, and personality unaltered-->

	[[Shinichi Kudo\|Shinichi]], the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[Episode 1]]. Later, [[Shiho Miyano]] was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.		[[Shinichi Kudo\|Shinichi]], the series' protagonist, was forced by Gin and Vodka to take the poison with the intention of killing him silently due to the police being around in [[Episode 1]]. Later, [[Shiho Miyano]] was set to be executed for being a possible loose end after Gin and Vodka killed her sister Akemi. Instead of letting herself be murdered, Shiho took her own poison intending to commit suicide; however, her body was reverted back to a childhood state like Shinichi's.
Line 18:		Line 18:

	== Name origin ==		== Name origin ==
	APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced ~~<!--The 8 is read with yattsu's "ya", not hachi's 'ha". That makes the katakana シャロク Sharoku -->~~"Shi-Ya-~~RoKu~~" ~~(シャロク ''Sharoku'')~~<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> in ~~the Sino-~~Japanese ~~version pronunciations of the numbers~~, which sounds like Sherlock. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. Maybe this means that APTX 4869 was developed to keep young, not ~~killing~~ people.		APTX 4869 is a pun on "Sherlock Holmes". 4869 can also be pronounced "Shi-Ya-Roku"<ref>Manga [[Volume 24]], File 10 (241), Page 11: "The Bullet from the Past"</ref> using [[wikipedia:Numeric substitution in Japanese\|numeric substitution]], which sounds like {{nihongo\|Sherlock\|シャーロック\|Shārokku}}. Adding to the pun, the password for the APTX data is "Shellingford"<ref>Manga [[Volume 24]], File 10 (241), page 11: " The Bullet from the Past". This has been confirmed to be spelled as "Shellingford" in the original Japanese.</ref>, an unintentional misspelling of "Sherrinford", which was the name Arthur Conan Doyle called his detective character before deciding on "Sherlock".<ref>"The name comes from Arthur Conan Doyle's earliest notes for A Study in Scarlet, which gave the great detective's name as "Sherrinford Holmes" and that of his medical companion as "Ormond Sacker"." {{cite web\|url=http://www.sherlockian.net/societies/baringgould.html\|date=2010\|accessdate=2012-01-28\|publisher=Chris Redmond\|title=Sherlockian.Net: William S. Baring-Gould}}</ref> The password and the pun name seem to be related to why several members of the Black Organization call APTX 4869 the "incomplete detective"<ref name="239p4">Manga [[Volume 24]], File 8 (239), pg 4: "The Black Burial Ranks". Gin is conversing with Pisco and tells him, "Of course, it's up to you if you use the 'Incomplete Detective' or not...". Earlier on the phone, Gin had mentioned it was fine if Pisco used the drug which both Haibara and Conan took to mean APTX 4869.</ref><ref name="241p11">Manga [[Volume 24]], File 10 (241), page 11: "A Bullet from the Past". Haibara tells Conan that "the members of the Organization sometimes gave this uncompleted drug a nickname... 'the Incomplete Detective'."</ref>, implying APTX 4869 is not finished yet. Maybe this means that APTX 4869 was developed to keep young, not kill people.

	== Antidote ==		== Antidote ==

Tsutomu25 at 12:23, 3 January 2024

2024-01-03T12:23:15Z

← Older revision		Revision as of 12:23, 3 January 2024
Line 50:		Line 50:

	It is also notable that Vermouth has been a part of the Black Organization long enough to have heard the Miyanos use the name "Silver Bullet",<ref>Vermouth has been in the Organization at least 20 years dated by when she assassinated Jodie's father which is more time than the theoretical maximum 18 years the tapes could be recorded -- dated to Shiho's conception.</ref> and may have given Conan the same nickname in reference to his deaged state caused by the drug. On the other hand, [[Shuichi Akai]] also has the nickname Silver Bullet, but no apparent connection to the drug other than dating Akemi Miyano, the sister/daughter of the drug's creators.		It is also notable that Vermouth has been a part of the Black Organization long enough to have heard the Miyanos use the name "Silver Bullet",<ref>Vermouth has been in the Organization at least 20 years dated by when she assassinated Jodie's father which is more time than the theoretical maximum 18 years the tapes could be recorded -- dated to Shiho's conception.</ref> and may have given Conan the same nickname in reference to his deaged state caused by the drug. On the other hand, [[Shuichi Akai]] also has the nickname Silver Bullet, but no apparent connection to the drug other than dating Akemi Miyano, the sister/daughter of the drug's creators.

			==See also==
			* [[Unsolved Mysteries]]

	== References ==		== References ==